Biology:3-(3-hydroxyphenyl)propanoate hydroxylase
From HandWiki
Short description: Class of enzymes
| 3-(3-hydroxyphenyl)propanoate hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.127 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3-(3-hydroxyphenyl)propanoate hydroxylase (EC 1.14.13.127, mhpA (gene)) is an enzyme with systematic name 3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- (1) 3-(3-hydroxyphenyl)propanoate + NADH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+
- (2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+
3-(3-hydroxyphenyl)propanoate hydroxylase is a flavoprotein (FAD).
References
- ↑ "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". Journal of Bacteriology 155 (1): 113–21. July 1983. PMID 6345502.
- ↑ "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". Journal of Bacteriology 168 (1): 55–64. October 1986. PMID 3531186.
- ↑ "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". Journal of Bacteriology 179 (8): 2573–81. April 1997. PMID 9098055.
- ↑ "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". Journal of Bacteriology 180 (11): 2915–23. June 1998. PMID 9603882.
External links
- 3-(3-hydroxyphenyl)propanoate+hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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