Biology:3-(imidazol-5-yl)lactate dehydrogenase
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Short description: Class of enzymes
| 3-(imidazol-5-yl)lactate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.111 | ||||||||
| CAS number | 37250-42-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 3-(imidazol-5-yl)lactate dehydrogenase (EC 1.1.1.111) is an enzyme that catalyzes the chemical reaction
- (S)-3-(imidazol-5-yl)lactate + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] 3-(imidazol-5-yl)pyruvate + NAD(P)H + H+
The 3 substrates of this enzyme are (S)-3-(imidazol-5-yl)lactate, NAD+, and NADP+, whereas its 4 products are 3-(imidazol-5-yl)pyruvate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase. This enzyme is also called imidazol-5-yl lactate dehydrogenase.
References
- "The role of imidazol-5-yl-lactate-nicotinamide-adenine dinucleotide phosphate oxidoreductase and histidine-2-oxoglutarate aminotransferase in the degradation of imidazol-5-yl-lactate by Pseudomonas acidovorans". The Biochemical Journal 111 (2): 237–9. January 1969. PMID 4303364.
- "[Identification and purification of an alpha-ketoacid aromatic reductase of Escherichia coli B]" (in French). Comptes Rendus des Séances de la Société de Biologie et de ses Filiales 162 (2): 390–5. 1968. PMID 4237631.
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