Biology:3-Isopropylmalate dehydrogenase
From HandWiki
Short description: InterPro Family
| 3-Isopropylmalate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.85 | ||||||||
| CAS number | 9030-97-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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3-Isopropylmalate dehydrogenase (EC 1.1.1.85) is an enzyme that is a part of the isopropylmalate dehydrogenase family, which catalyzes the chemical reactions:[1][2][3][4]
- (2R,3S)-3-isopropylmalate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 4-methyl-2-oxopentanoate + CO2 + NADH
- (2R,3S)-3-isopropylmalate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] (2S)-2-isopropyl-3-oxosuccinate + H+ + NADH
- (2S)-2-isopropyl-3-oxosuccinate + H+ [math]\displaystyle{ \rightleftharpoons }[/math] 4-methyl-2-oxopentanoate + CO2
References
- ↑ "The biosynthesis of leucine. III. The conversion of α-hydroxy-β-carboxyisocaproate to α-ketoisocaproate.". Biochemistry 2 (5): 1053–8. 1963. doi:10.1021/bi00905a024. PMID 14087358.
- ↑ "The Absolute Configuration of α-carboxyisocaproic Acid (3-Isopropylmalic Acid), an Intermediate in Leucine Biosynthesis". Biochemistry 3 (12): 2024–7. December 1964. doi:10.1021/bi00900a043. PMID 14269331.
- ↑ "Purification and Properties of β-Isopropylmalate Dehydrogenase". J. Biol. Chem. 244 (3): 996–1003. February 1969. PMID 4889950.
- ↑ "Mirror image mutations reveal the significance of an intersubunit ion cluster in the stability of 3-isopropylmalate dehydrogenase". FEBS Lett. 468 (1): 48–52. February 2000. doi:10.1016/S0014-5793(00)01190-X. PMID 10683439.
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