Biology:3-phenylpropanoate dioxygenase
| 3-phenylpropanoate dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.12.19 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, a 3-phenylpropanoate dioxygenase (EC 1.14.12.19) is an enzyme that catalyzes the chemical reaction
- 3-phenylpropanoate + NADH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+
The 4 substrates of this enzyme are 3-phenylpropanoate, NADH, H+, and O2, whereas its two products are 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate and NAD+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is 3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating). Other names in common use include HcaA1A2CD, Hca dioxygenase, and 3-phenylpropionate dioxygenase.
References
- "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". J. Bacteriol. 180 (11): 2915–23. 1998. PMID 9603882.
- "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". J. Bacteriol. 155 (1): 113–21. 1983. PMID 6345502.
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