Biology:3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
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Short description: Enzyme
| 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.239 | ||||||||
| CAS number | 126469-82-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) (EC 1.1.1.239) is an enzyme that catalyzes the chemical reaction:
- testosterone + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] androst-4-ene-3,17-dione + NADH + H+
Thus, the two substrates of this enzyme are testosterone and NAD+, whereas its 3 products are androst-4-ene-3,17-dione, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase. Other names in common use include 3alpha,17beta-hydroxy steroid dehydrogenase, 3alpha(17beta)-HSD, and 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+). This enzyme participates in androgen and estrogen metabolism.
References
- "Demonstration of 3α(17β)-hydroxysteroid dehydrogenase distinct from 3α-hydroxysteroid dehydrogenase in hamster liver". Biochem. J. 266 (2): 583–9. 1990. PMID 2317205.
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