Biology:3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase
| 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.152 | ||||||||
| CAS number | 37250-77-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase (EC 1.1.1.152) is an enzyme that catalyzes the chemical reaction
- 3alpha-hydroxy-5beta-androstane-17-one + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 5beta-androstane-3,17-dione + NADH + H+
Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-androstane-17-one and NAD+, whereas its 3 products are 5beta-androstane-3,17-dione, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase. Other names in common use include etiocholanolone 3alpha-dehydrogenase, etiocholanolone 3alpha-dehydrogenase, and 3alpha-hydroxy-5beta-steroid dehydrogenase. This enzyme participates in androgen and estrogen metabolism.
References
- "Purification and substrate specificities of bacterial hydroxysteroid dehydrogenases". Biochemistry 8 (12): 5093–103. 1969. doi:10.1021/bi00840a063. PMID 5365796.
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