Biology:6-Hydroxynicotinate 3-monooxygenase
From HandWiki
Short description: Class of enzymes
| 6-Hydroxynicotinate 3-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.114 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
6-Hydroxynicotinate 3-monooxygenase (EC 1.14.13.114, NicC, 6HNA monooxygenase, HNA-3-monooxygenase) is an enzyme with systematic name 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating).[1][2] This enzyme catalyses the following chemical reaction
- 6-hydroxynicotinate + NADH + H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 2,5-dihydroxypyridine + NAD+ + H2O + CO2
6-Hydroxynicotinate 3-monooxygenase a flavoprotein (FAD).
References
- ↑ "Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5". European Journal of Biochemistry 260 (1): 120–6. February 1999. doi:10.1046/j.1432-1327.1999.00124.x. PMID 10091591.
- ↑ "Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440". Proceedings of the National Academy of Sciences of the United States of America 105 (32): 11329–34. August 2008. doi:10.1073/pnas.0802273105. PMID 18678916. Bibcode: 2008PNAS..10511329J.
External links
- 6-hydroxynicotinate+3-monooxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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