Biology:7beta-hydroxysteroid dehydrogenase (NADP+)
From HandWiki
Short description: Class of enzymes
| 7-beta-hydroxysteroid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.201 | ||||||||
| CAS number | 79393-83-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 7beta-hydroxysteroid dehydrogenase (NADP+) (EC 1.1.1.201) is an enzyme that catalyzes the chemical reaction
- a 7beta-hydroxysteroid + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] a 7-oxosteroid + NADPH + H+
Thus, the two substrates of this enzyme are 7beta-hydroxysteroid and NADP+, whereas its 3 products are 7-oxosteroid, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 7beta-hydroxysteroid:NADP+ 7-oxidoreductase. Other names in common use include NADP+-dependent 7beta-hydroxysteroid dehydrogenase, and 7beta-hydroxysteroid dehydrogenase (NADP+).
References
- "Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity". Proteins 84 (6): 859–65. June 2016. doi:10.1002/prot.25036. PMID 27006087.
- "Characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens". Applied and Environmental Microbiology 43 (5): 1057–63. May 1982. doi:10.1128/AEM.43.5.1057-1063.1982. PMID 6954878. Bibcode: 1982ApEnM..43.1057H.
- "Bile induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum". Biochimica et Biophysica Acta 665 (2): 262–9. August 1981. doi:10.1016/0005-2760(81)90011-4. PMID 6945134.
- "Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7 beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7 alpha-hydroxysteroid dehydrogenase-elaborating organisms". Applied and Environmental Microbiology 44 (5): 1187–95. November 1982. doi:10.1128/AEM.44.5.1187-1195.1982. PMID 6758698. Bibcode: 1982ApEnM..44.1187M.
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