Biology:A4GALT
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.[1][2]
The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.[2]
References
- ↑ "Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals.". J Biol Chem 275 (33): 25315–21. Sep 2000. doi:10.1074/jbc.M002630200. PMID 10854428.
- ↑ 2.0 2.1 "Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53947.
Further reading
- "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.". J. Biol. Chem. 275 (22): 16723–9. 2000. doi:10.1074/jbc.M000728200. PMID 10747952.
- "Molecular cloning of globotriaosylceramide/CD77 synthase, a glycosyltransferase that initiates the synthesis of globo series glycosphingolipids.". J. Biol. Chem. 275 (20): 15152–6. 2000. doi:10.1074/jbc.M909620199. PMID 10748143.
- "Molecular basis for the p phenotype. Identification of distinct and multiple mutations in the alpha 1,4-galactosyltransferase gene in Swedish and Japanese individuals.". J. Biol. Chem. 275 (48): 37752–6. 2001. doi:10.1074/jbc.C000625200. PMID 10993874.
- "Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins.". J. Biol. Chem. 277 (13): 11247–54. 2002. doi:10.1074/jbc.M109519200. PMID 11782470.
- "Three-base deletion and one-base insertion of the alpha(1,4)galactosyltransferase gene responsible for the P phenotype.". Transfusion 42 (1): 48–51. 2002. doi:10.1046/j.1537-2995.2002.00014.x. PMID 11896312.
- Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H. et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene. A clue to the solution of the P1/P2/p puzzle.". J. Biol. Chem. 278 (45): 44429–38. 2004. doi:10.1074/jbc.M301609200. PMID 12888565.
- "Genetic heterogeneity at the glycosyltransferase loci underlying the GLOB blood group system and collection.". Br. J. Haematol. 125 (4): 528–36. 2004. doi:10.1111/j.1365-2141.2004.04930.x. PMID 15142124.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
External links
- A4GALT human gene location in the UCSC Genome Browser.
- A4GALT human gene details in the UCSC Genome Browser.
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