Biology:ACER1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.[1]
Function
ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).[1]
References
External links
- Human ACER1 genome location and ACER1 gene details page in the UCSC Genome Browser.
Further reading
- "Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes". The Journal of Investigative Dermatology 128 (2): 389–97. Feb 2008. doi:10.1038/sj.jid.5701025. PMID 17713573.
- "Large-scale identification of human genes implicated in epidermal barrier function". Genome Biology 8 (6): R107. 2007. doi:10.1186/gb-2007-8-6-r107. PMID 17562024.
- "[Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme 47 (4 Suppl): 455–62. Mar 2002. PMID 11915342.
- "Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis". Journal of Lipid Research 47 (5): 1063–70. May 2006. doi:10.1194/jlr.M600001-JLR200. PMID 16477081.
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