Biology:ADCY3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene.[1][2]
Function
This gene encodes adenylyl cyclase 3, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP).[2]
The ADCY3 subtype likely mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.[3]
References
- ↑ "Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets". Biochemical and Biophysical Research Communications 254 (3): 548–551. Jan 1999. doi:10.1006/bbrc.1998.9983. PMID 9920776.
- ↑ 2.0 2.1 "Entrez Gene: ADCY3 adenylate cyclase 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=109.
- ↑ "Gene Cards: ADCY3 Gene". https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADCY3.
External links
- Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome Browser.
Further reading
- "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Human Genetics 94 (5): 527–9. Nov 1994. doi:10.1007/BF00211020. PMID 7959689.
- "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Human Genetics 94 (1): 69–73. Jul 1994. doi:10.1007/BF02272844. PMID 8034296.
- "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line". Biochemical and Biophysical Research Communications 192 (1): 311–318. Apr 1993. doi:10.1006/bbrc.1993.1415. PMID 8476432.
- "Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo". The Journal of Biological Chemistry 271 (39): 24231–24235. Sep 1996. doi:10.1074/jbc.271.39.24231. PMID 8798667.
- "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (1): 31–39. Feb 1998. doi:10.1093/dnares/5.1.31. PMID 9628581.
- "Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals". Neuron 21 (3): 495–504. Sep 1998. doi:10.1016/S0896-6273(00)80561-9. PMID 9768837.
- "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv 437 (4): 538–546. Mar 1999. doi:10.1007/s004240050815. PMID 10089566.
- "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS 14 (6): 629–636. Apr 2000. doi:10.1097/00002030-200004140-00001. PMID 10807185.
- "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology 105 (5): 975–982. May 2000. doi:10.1067/mai.2000.105315. PMID 10808179.
- "Expression of multiple adenylyl cyclase isoforms in human and dog thyroid". Molecular and Cellular Endocrinology 170 (1–2): 185–196. Dec 2000. doi:10.1016/S0303-7207(00)00322-1. PMID 11162902.
- "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry 77 (2): 399–407. Apr 2001. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
- "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". The Journal of Clinical Endocrinology and Metabolism 86 (9): 4495–4503. Sep 2001. doi:10.1210/jcem.86.9.7837. PMID 11549699.
- "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology 76 (7): 3179–3188. Apr 2002. doi:10.1128/JVI.76.7.3179-3188.2002. PMID 11884542.
- "Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons". The Journal of Neuroscience 22 (14): 5931–7. Jul 2002. doi:10.1523/JNEUROSCI.22-14-05931.2002. PMID 12122055.
- "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research 22 (1–4): 79–110. 2003. doi:10.1081/RRS-120014589. PMID 12503609.
- "Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets". Platelets 14 (1): 21–33. Feb 2003. doi:10.1080/0953710021000062905. PMID 12623444. https://zenodo.org/record/896544.
- "Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules". Molecular and Cellular Endocrinology 203 (1–2): 129–135. May 2003. doi:10.1016/S0303-7207(03)00086-8. PMID 12782409.
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