Biology:GUCY1A3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.[1][2]
Function
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[2] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).
References
- ↑ "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett 304 (1): 83–8. Jul 1992. doi:10.1016/0014-5793(92)80594-7. PMID 1352257.
- ↑ 2.0 2.1 "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2982.
Further reading
- "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33.". Hum. Genet. 91 (3): 257–60. 1993. doi:10.1007/BF00218267. PMID 8097486.
- "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue.". J. Cell. Physiol. 167 (2): 213–21. 1996. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
- "Human soluble guanylate cyclase: functional expression and revised isoenzyme family.". Biochem. J. 335 (1): 51–7. 1998. doi:10.1042/bj3350051. PMID 9742212.
- "A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?". Gene 245 (2): 319–28. 2000. doi:10.1016/S0378-1119(00)00019-6. PMID 10717483.
- "Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization.". Cytogenet. Cell Genet. 88 (3–4): 204–5. 2000. doi:10.1159/000015548. PMID 10828587.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3". Oncol. Rep. 12 (1): 47–52. 2005. doi:10.3892/or.12.1.47. PMID 15201957.
- "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. 2005. doi:10.1074/jbc.M410565200. PMID 15381706.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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