Biology:NPR2

Short description: Protein-coding gene in Homo sapiens

Generic protein structure example

Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), also known as NPR2, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR2 gene.

A mutation of the NPR2 gene can result in disproportionate dwarfism with short limbs.

See also

• Atrial natriuretic peptide receptor
• Dwarfism

Further reading

• "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting". Anesthesiology 110 (4): 738–47. April 2009. doi:10.1097/ALN.0b013e31819c7496. PMID 19326473. 
• "Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B". The Journal of Biological Chemistry 279 (47): 48513–9. November 2004. doi:10.1074/jbc.M408247200. PMID 15371450. 
• "Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al". Diabetes Care 27 (3): 848; author reply 848-9. March 2004. doi:10.2337/diacare.27.3.848. PMID 14988324. 
• "ATP-independent activation of natriuretic peptide receptors". The Journal of Biological Chemistry 280 (29): 26928–32. July 2005. doi:10.1074/jbc.M505648200. PMID 15911610. 
• "SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension". Polskie Archiwum Medycyny Wewnetrznej 119 (4): 219–24. April 2009. PMID 19413180. 
• "Molecular biology of the natriuretic peptides and their receptors". Circulation 86 (4): 1081–8. October 1992. doi:10.1161/01.cir.86.4.1081. PMID 1327579. 
• "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize". Molecular Pharmacology 67 (1): 174–83. January 2005. doi:10.1124/mol.104.002436. PMID 15459247. 
• "Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy". Journal of Molecular Medicine 85 (8): 797–810. August 2007. doi:10.1007/s00109-007-0183-4. PMID 17429599. https://zenodo.org/record/1232599. 
• "Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1". Hypertension 44 (3): 283–8. September 2004. doi:10.1161/01.HYP.0000136908.60317.92. PMID 15262909. 
• "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux". Human Molecular Genetics 18 (2): 267–77. January 2009. doi:10.1093/hmg/ddn354. PMID 18945719. 
• "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides 26 (6): 1024–34. June 2005. doi:10.1016/j.peptides.2004.08.027. PMID 15911070. 
• "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation". The Journal of Biological Chemistry 284 (29): 19196–202. July 2009. doi:10.1074/jbc.M109.010777. PMID 19458086. 
• "B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement". Journal of Cardiothoracic and Vascular Anesthesia 23 (2): 161–5. April 2009. doi:10.1053/j.jvca.2008.11.006. PMID 19167912. 
• "Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development". The Journal of Clinical Endocrinology and Metabolism 92 (10): 4009–14. October 2007. doi:10.1210/jc.2007-1101. PMID 17652215. 
• "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 150B (6): 808–16. September 2009. doi:10.1002/ajmg.b.30902. PMID 19086053. 
• "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux". American Journal of Human Genetics 75 (1): 27–34. July 2004. doi:10.1086/422013. PMID 15146390. 
• "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors". Journal of Molecular Biology 311 (5): 923–37. August 2001. doi:10.1006/jmbi.2001.4922. PMID 11556325. 

External links

• NPR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.