Biology:ADCY5

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene.

Interactions

ADCY5 has been shown to interact with RGS2.

Clinical significance

Mutations in ADCY5 are known to cause the following conditions:

• Dyskinesia with orofacial involvement, autosomal recessive (DSKOR);
• Neurodevelopmental disorder with hyperkinetic movements and dyskinesia (NEDHYD).

External links

• Human ADCY5 genome location and ADCY5 gene details page in the UCSC Genome Browser.

Further reading

• "Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells". Proc. Natl. Acad. Sci. U.S.A. 89 (15): 6716–20. 1992. doi:10.1073/pnas.89.15.6716. PMID 1379717. Bibcode: 1992PNAS...89.6716Y. 
• "Regulation of adenylyl cyclase by protein kinase A". J. Biol. Chem. 270 (21): 12481–4. 1995. doi:10.1074/jbc.270.21.12481. PMID 7759492. 
• "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI". Hum. Genet. 94 (1): 69–73. 1994. doi:10.1007/BF02272844. PMID 8034296. 
• "Differential activation of adenylyl cyclase by protein kinase C isoenzymes". J. Biol. Chem. 269 (24): 16554–8. 1994. doi:10.1016/S0021-9258(19)89424-3. PMID 8206971. 
• "Characterization of soluble forms of nonchimeric type V adenylyl cyclases". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2915–20. 1997. doi:10.1073/pnas.94.7.2915. PMID 9096321. Bibcode: 1997PNAS...94.2915S. 
• "Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase". J. Biol. Chem. 272 (35): 22265–71. 1997. doi:10.1074/jbc.272.35.22265. PMID 9268375. 
• "Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsα". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9602–7. 1997. doi:10.1073/pnas.94.18.9602. PMID 9275169. Bibcode: 1997PNAS...94.9602S. 
• "Identification of a Gialpha binding site on type V adenylyl cyclase". J. Biol. Chem. 273 (40): 25831–9. 1998. doi:10.1074/jbc.273.40.25831. PMID 9748257. 
• "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Arch. 437 (4): 538–46. 1999. doi:10.1007/s004240050815. PMID 10089566. 
• "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS 14 (6): 629–36. 2000. doi:10.1097/00002030-200004140-00001. PMID 10807185. 
• "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. 2000. doi:10.1067/mai.2000.105315. PMID 10808179. 
• "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. 2001. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302. 
• "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. 2001. doi:10.1210/jcem.86.9.7837. PMID 11549699. 
• "Mechanism of Human Immunodeficiency Virus-Induced Complement Expression in Astrocytes and Neurons". J. Virol. 76 (7): 3179–88. 2002. doi:10.1128/JVI.76.7.3179-3188.2002. PMID 11884542. 
• "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. 2003. doi:10.1081/RRS-120014589. PMID 12503609. 
• "Identification of RGS2 and type V adenylyl cyclase interaction sites". J. Biol. Chem. 278 (18): 15842–9. 2003. doi:10.1074/jbc.M210663200. PMID 12604604. 
• "Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes". Mol. Cell 23 (6): 925–31. 2006. doi:10.1016/j.molcel.2006.07.025. PMID 16973443. 
• "Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor". Biochem J 406 (3): 383–8. 2007. doi:10.1042/BJ20070512. PMID 17593019.