Biology:ADCY8
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.[1][2]
Function
Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.[2]
References
- ↑ "Molecular cloning of the human type VIII adenylyl cyclase". FEBS Letters 351 (1): 109–13. Aug 1994. doi:10.1016/0014-5793(94)00836-1. PMID 8076676.
- ↑ 2.0 2.1 "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114.
External links
- Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome Browser.
- Human ADCY8 genome location and ADCY8 gene details page in the UCSC Genome Browser.
Further reading
- "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain". Human Genetics 90 (1–2): 126–30. 1992. doi:10.1007/BF00210755. PMID 1427768.
- "Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain". Biochemical and Biophysical Research Communications 179 (1): 455–62. Aug 1991. doi:10.1016/0006-291X(91)91392-P. PMID 1715695.
- "Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain". The Journal of Biological Chemistry 269 (16): 12190–5. Apr 1994. doi:10.1016/S0021-9258(17)32700-X. PMID 8163524.
- "Calmodulin-binding sites on adenylyl cyclase type VIII". The Journal of Biological Chemistry 274 (12): 8012–21. Mar 1999. doi:10.1074/jbc.274.12.8012. PMID 10075700.
- "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv 437 (4): 538–46. Mar 1999. doi:10.1007/s004240050815. PMID 10089566.
- "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS 14 (6): 629–36. Apr 2000. doi:10.1097/00002030-200004140-00001. PMID 10807185.
- "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology 105 (5): 975–82. May 2000. doi:10.1067/mai.2000.105315. PMID 10808179.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry 77 (2): 399–407. Apr 2001. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302.
- "A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones". Brain Research. Molecular Brain Research 91 (1–2): 43–9. Jul 2001. doi:10.1016/S0169-328X(01)00119-X. PMID 11457491.
- "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology 76 (7): 3179–88. Apr 2002. doi:10.1128/JVI.76.7.3179-3188.2002. PMID 11884542.
- "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research 22 (1–4): 79–110. 2003. doi:10.1081/RRS-120014589. PMID 12503609.
- "Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8)". FASEB Journal 17 (11): 1380–91. Aug 2003. doi:10.1096/fj.02-0784com. PMID 12890691. https://hal.archives-ouvertes.fr/hal-03161433/file/Version%20HAL.pdf.
- "A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A". Molecular Pharmacology 69 (2): 608–17. Feb 2006. doi:10.1124/mol.105.018275. PMID 16258073.
- "The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8". The Journal of Biological Chemistry 281 (25): 17379–89. Jun 2006. doi:10.1074/jbc.M510992200. PMID 16613843.
- "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Letters 581 (17): 3241–6. Jul 2007. doi:10.1016/j.febslet.2007.06.015. PMID 17586501.
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