Biology:GUCY1B3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.[1][2]
Function
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[2]
Interactions
GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[3] and Endothelial NOS.[3]
References
- ↑ "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett 304 (1): 83–8. Jul 1992. doi:10.1016/0014-5793(92)80594-7. PMID 1352257.
- ↑ 2.0 2.1 "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983.
- ↑ 3.0 3.1 "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. Aug 2003. doi:10.1152/ajpheart.01025.2002. PMID 12676772.
Further reading
- "Guanylyl cyclases and signaling by cyclic GMP". Pharmacol. Rev. 52 (3): 375–414. 2000. PMID 10977868.
- "Heterogeneity in human soluble guanylate cyclase due to alternative splicing". FEBS Lett. 290 (1–2): 157–8. 1991. doi:10.1016/0014-5793(91)81248-7. PMID 1680753.
- "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. 1993. doi:10.1007/BF00218267. PMID 8097486.
- "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. 1996. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461.
- "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. 1998. doi:10.1042/bj3350051. PMID 9742212.
- "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. 2002. doi:10.1074/jbc.M105587200. PMID 11572861.
- "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. 2003. doi:10.1152/ajpheart.01025.2002. PMID 12676772.
- "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. 2005. doi:10.1074/jbc.M410565200. PMID 15381706.
- "Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction". Int. J. Impot. Res. 18 (5): 432–7. 2006. doi:10.1038/sj.ijir.3901461. PMID 16528291.
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