Biology:NPR1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).

It is localized in the kidney where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.

See also

• Atrial natriuretic peptide receptor

Further reading

• Pandey KN (2002). "Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments.". Mol. Cell. Biochem. 230 (1–2): 61–72. doi:10.1023/A:1014240006767. PMID 11952097. 
• "[Natriuretic peptides and essential arterial hypertension]". Italian Heart Journal Supplement 3 (11): 1085–91. 2003. PMID 12506509. 
• Pandey KN (2005). "Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A". Peptides 26 (6): 985–1000. doi:10.1016/j.peptides.2004.12.020. PMID 15911067. 
• "Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression". Peptides 26 (6): 1009–23. 2005. doi:10.1016/j.peptides.2004.09.022. PMID 15911069. 

External links

• NPR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.