Biology:Anthraniloyl-CoA monooxygenase

From HandWiki
Short description: Class of enzymes
anthraniloyl-CoA monooxygenase
Identifiers
EC number1.14.13.40
CAS number112692-57-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an anthraniloyl-CoA monooxygenase (EC 1.14.13.40) is an enzyme that catalyzes the chemical reaction

2-aminobenzoyl-CoA + 2 NAD(P)H + 2 H+ + O2 [math]\displaystyle{ \rightleftharpoons }[/math] 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NAD(P)+

The 5 substrates of this enzyme are 2-aminobenzoyl-CoA, NADH, NADPH, H+, and O2, whereas its 4 products are 2-amino-5-oxocyclohex-1-enecarboxyl-CoA, H2O, NAD+, and NADP+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing). Other names in common use include anthraniloyl coenzyme A reductase, and 2-aminobenzoyl-CoA monooxygenase/reductase. This enzyme participates in carbazole degradation. It employs one cofactor, FAD.

References