Biology:BSD domain

From HandWiki
BSD
PDB 2dii EBI.jpg
solution structure of the bsd domain of human tfiih basal transcription factor complex p62 subunit
Identifiers
SymbolBSD
PfamPF03909
InterProIPR005607

In molecular biology, the BSD domain is an approximately 60-amino-acid-long protein domain named after the BTF2-like transcription factors, synapse-associated proteins and DOS2-like proteins in which it is found. It is also found in several hypothetical proteins. It occurs in one or two copies in a variety of species ranging from primal protozoan to human, and can be found associated with other domains such as the BTB domain or the U-box in multidomain proteins. Its function is as yet unknown.[1]

Secondary structure prediction indicates the presence of three predicted alpha helices, which probably form a three-helical bundle in small |domains. The third predicted helix contains neighbouring phenylalanine and tryptophan residues—less common amino acids that are invariant in all the BSD domains identified and that are the domain's most striking sequence features.[1]

Some proteins known to contain one or two BSD domains are:

References

  1. 1.0 1.1 "BSD: a novel domain in transcription factors and synapse-associated proteins". Trends in Biochemical Sciences 27 (4): 168–70. April 2002. doi:10.1016/s0968-0004(01)02042-4. PMID 11943536. 

Further reading