Biology:GTF2H1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.[1][2][3]
Interactions
GTF2H1 has been shown to interact with:
- Cyclin-dependent kinase 7,[4][5][6]
- E2F1,[7]
- ERCC2,[4][8]
- Estrogen receptor alpha,[9]
- TCEA1,[10][11] and
- XPB.[4][12][13]
See also
- Transcription Factor II H
References
- ↑ "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science 257 (5075): 1392–5. October 1992. doi:10.1126/science.1529339. PMID 1529339. Bibcode: 1992Sci...257.1392F.
- ↑ "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. May 1994. doi:10.1093/hmg/3.1.61. PMID 8162052.
- ↑ "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2965.
- ↑ 4.0 4.1 4.2 "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. April 1997. doi:10.1093/emboj/16.7.1628. PMID 9130708.
- ↑ "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature 374 (6519): 283–7. March 1995. doi:10.1038/374283a0. PMID 7533895. Bibcode: 1995Natur.374..283S.
- ↑ "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. 55 (24): 6058–62. December 1995. PMID 8521393.
- ↑ "Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase". EMBO J. 18 (15): 4280–91. August 1999. doi:10.1093/emboj/18.15.4280. PMID 10428966.
- ↑ "Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II". Nature 368 (6473): 769–72. April 1994. doi:10.1038/368769a0. PMID 8152490. Bibcode: 1994Natur.368..769D.
- ↑ "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7". Mol. Cell 6 (1): 127–37. July 2000. doi:10.1016/s1097-2765(00)00014-9. PMID 10949034.
- ↑ "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. October 1998. doi:10.1074/jbc.273.42.27593. PMID 9765293.
- ↑ "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39): 24563–71. September 1997. doi:10.1074/jbc.272.39.24563. PMID 9305922.
- ↑ "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. 36 (7): 714–9. July 2004. doi:10.1038/ng1387. PMID 15220921.
- ↑ "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. March 1997. doi:10.1093/emboj/16.5.1093. PMID 9118947.
Further reading
- "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. 1998. doi:10.1007/BF02253352. PMID 9570510.
- "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447-9. 1998. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670.
- "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature 374 (6519): 283–7. 1995. doi:10.1038/374283a0. PMID 7533895. Bibcode: 1995Natur.374..283S.
- "The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3259–63. 1995. doi:10.1073/pnas.92.8.3259. PMID 7724549. Bibcode: 1995PNAS...92.3259T.
- "A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1". Genomics 25 (2): 447–61. 1995. doi:10.1016/0888-7543(95)80045-N. PMID 7789978.
- "Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53". Mol. Cell. Biol. 14 (10): 7013–24. 1994. doi:10.1128/mcb.14.10.7013. PMID 7935417.
- "The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor". EMBO J. 13 (10): 2388–92. 1994. doi:10.1002/j.1460-2075.1994.tb06522.x. PMID 8194528.
- "Three functional classes of transcriptional activation domain". Mol. Cell. Biol. 16 (5): 2044–55. 1996. doi:10.1128/MCB.16.5.2044. PMID 8628270.
- "Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein". Biochemistry 35 (7): 2157–67. 1996. doi:10.1021/bi9524124. PMID 8652557.
- "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6482–7. 1996. doi:10.1073/pnas.93.13.6482. PMID 8692841. Bibcode: 1996PNAS...93.6482R.
- "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6488–93. 1996. doi:10.1073/pnas.93.13.6488. PMID 8692842. Bibcode: 1996PNAS...93.6488D.
- "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science 274 (5287): 605–10. 1996. doi:10.1126/science.274.5287.605. PMID 8849451. Bibcode: 1996Sci...274..605Z.
- "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature 384 (6607): 375–8. 1996. doi:10.1038/384375a0. PMID 8934526. Bibcode: 1996Natur.384..375P.
- "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. 1997. doi:10.1074/jbc.272.11.6951. PMID 9054383.
- "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. 1997. doi:10.1093/emboj/16.5.1093. PMID 9118947.
- "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme". Mol. Cell. Biol. 17 (4): 1817–23. 1997. doi:10.1128/mcb.17.4.1817. PMID 9121429.
- "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. 16 (7): 1628–37. 1997. doi:10.1093/emboj/16.7.1628. PMID 9130708.
- "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription". EMBO J. 16 (10): 2836–50. 1997. doi:10.1093/emboj/16.10.2836. PMID 9184228.
External links
- GTF2H1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P32780 (General transcription factor IIH subunit 1) at the PDBe-KB.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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