Biology:Cathepsin W
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cathepsin W is a protein that in humans is encoded by the CTSW gene.[1][2][3]
The protein encoded by this gene, a member of the peptidase C1 family of cysteine cathepsins, is a cysteine protease cathepsin that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the cell membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.[3]
References
- ↑ "Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes". FEBS Lett 405 (3): 253–9. May 1997. doi:10.1016/S0014-5793(97)00118-X. PMID 9108299.
- ↑ "Genomic structure, chromosomal localization, and expression of human cathepsin W". Biochem Biophys Res Commun 248 (2): 255–61. Aug 1998. doi:10.1006/bbrc.1998.8954. PMID 9675123.
- ↑ 3.0 3.1 "Entrez Gene: CTSW cathepsin W". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1521.
Further reading
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene.". Biochem. Biophys. Res. Commun. 321 (4): 975–80. 2004. doi:10.1016/j.bbrc.2004.07.056. PMID 15358123.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract.". Biol. Chem. 383 (7–8): 1285–9. 2003. doi:10.1515/BC.2002.144. PMID 12437118.
- "Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.". J. Immunol. 167 (4): 2172–8. 2001. doi:10.4049/jimmunol.167.4.2172. PMID 11490002.
- "Human Cathepsins W and F form a New Subgroup of Cathepsins that is Evolutionary Separated from the Cathepsin B- and L-Like Cysteine Proteases". Cellular Peptidases in Immune Functions and Diseases 2. Advances in Experimental Medicine and Biology. 477. 2000. pp. 271–80. doi:10.1007/0-306-46826-3_29. ISBN 0-306-46383-0.
- "Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes.". Int. J. Biochem. Cell Biol. 32 (3): 373–84. 2000. doi:10.1016/S1357-2725(99)00129-6. PMID 10716634.
- "Human cathepsins F and W: A new subgroup of cathepsins.". Biochem. Biophys. Res. Commun. 259 (2): 401–7. 1999. doi:10.1006/bbrc.1999.0700. PMID 10362521.
- "Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.". Leukemia 12 (11): 1771–81. 1998. doi:10.1038/sj.leu.2401164. PMID 9823953.
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