Biology:Caspase 4

caspase 4, apoptosis-related cysteine peptidase
Identifiers
Symbol	CASP4
Alt. symbols	ICE(rel)II, ICH-2, TX
NCBI gene	837
HGNC	1505
OMIM	602664
RefSeq	NM_001225
UniProt	P49662
Other data
EC number	3.4.22.57
Locus	Chr. 11 q22.2-q22.3

Short description: Mammalian protein found in Homo sapiens

Caspase 4 is an enzyme that proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.^[1]

The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.^[2]

References

↑ "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. 2007. doi:10.1038/sj.cdd.4402038. PMID 16977329.
↑ "NSAIDs are Caspase Inhibitors". Cell Chem Biol 24 (3): 281–292. 2017. doi:10.1016/j.chembiol.2017.02.003. PMID 28238723.

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v t e Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)