Biology:Channel-conductance-controlling ATPase
From HandWiki
Short description: Class of enzymes
| channel-conductance-controlling ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.6.3.49 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a channel-conductance-controlling ATPase (EC 3.6.3.49) is an enzyme that catalyzes the chemical reaction
- ATP + H2O [math]\displaystyle{ \rightleftharpoons }[/math] ADP + phosphate
Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (channel-conductance-controlling).
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1XMI and 1XMJ.
References
- "Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes". Mol. Membr. Biol. 13 (1): 33–40. 1996. doi:10.3109/09687689609160572. PMID 9147660.
- "Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters". FEBS Lett. 402 (1): 1–3. 1997. doi:10.1016/S0014-5793(96)01478-0. PMID 9013845.
- "Structure and function of the CFTR chloride channel". Physiol. Rev. 79 (1 Suppl): S23–45. 1999. doi:10.1152/physrev.1999.79.1.S23. PMID 9922375.
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