Biology:Citrate (Re)-synthase
From HandWiki
| citrate (Re)-synthase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.3.3.3 | ||||||||
| CAS number | 9077-70-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a citrate (Re)-synthase (EC 2.3.3.3) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + H2O + oxaloacetate [math]\displaystyle{ \rightleftharpoons }[/math] citrate + CoA
The 3 substrates of this enzyme are acetyl-CoA, H2O, and oxaloacetate, whereas its two products are citrate and CoA.
This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]. Other names in common use include (R)-citrate synthase, Re-citrate-synthase, and citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA].
References
- "The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate". Biochem. Biophys. Res. Commun. 36 (5): 802–8. 1969. doi:10.1016/0006-291X(69)90680-9. PMID 5808294.
- Gottschalk G (1969). "Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici". Eur. J. Biochem. 7 (2): 301–6. doi:10.1111/j.1432-1033.1969.tb19607.x. PMID 4974734.
- "Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase". Biochemistry 5 (4): 1125–33. 1966. doi:10.1021/bi00868a003. PMID 5958189.
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