Biology:Cyclin E2
From HandWiki
Short description: Protein
| cyclin E2 | |
|---|---|
| Identifiers | |
| Symbol | CCNE2 |
| NCBI gene | 9134 |
| HGNC | 1590 |
| OMIM | 603775 |
| RefSeq | NM_057749 |
| UniProt | O96020 |
| Other data | |
| Locus | Chr. 8 q22.1 |
Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.[1]
References
- ↑ 1.0 1.1 "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology 19 (1): 612–22. January 1999. doi:10.1128/mcb.19.1.612. PMID 9858585.
- Zariwala, M.; Liu, J.; Xiong, Y. (1998-11-26). "Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins". Oncogene 17 (21): 2787–2798. doi:10.1038/sj.onc.1202505. ISSN 0950-9232. PMID 9840943. https://pubmed.ncbi.nlm.nih.gov/9840943/.
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