Biology:Cyclin B2

Generic protein structure example

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Function

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.

Interactions

Cyclin B2 has been shown to interact with TGF beta receptor 2.

See also

• Cyclin B

Further reading

• "Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity". J. Virol. 69 (11): 6705–11. 1995. doi:10.1128/JVI.69.11.6705-6711.1995. PMID 7474080. 
• "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B". J. Virol. 69 (11): 6859–64. 1995. doi:10.1128/JVI.69.11.6859-6864.1995. PMID 7474100. 
• "Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr". J. Virol. 69 (12): 7909–16. 1995. doi:10.1128/JVI.69.12.7909-7916.1995. PMID 7494303. 
• "The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle". J. Virol. 69 (10): 6304–13. 1995. doi:10.1128/JVI.69.10.6304-6313.1995. PMID 7666531. 
• "Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus". EMBO J. 14 (8): 1646–54. 1995. doi:10.1002/j.1460-2075.1995.tb07153.x. PMID 7737117. 
• "The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B". EMBO J. 13 (16): 3772–81. 1994. doi:10.1002/j.1460-2075.1994.tb06688.x. PMID 8070405. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard". J. Virol. 71 (5): 3961–71. 1997. doi:10.1128/JVI.71.5.3961-3971.1997. PMID 9094673. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3419–24. 1998. doi:10.1073/pnas.95.7.3419. PMID 9520381. Bibcode: 1998PNAS...95.3419M. 
• "Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4344–9. 1998. doi:10.1073/pnas.95.8.4344. PMID 9539739. Bibcode: 1998PNAS...95.4344B. 
• "HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5281–6. 1998. doi:10.1073/pnas.95.9.5281. PMID 9560267. Bibcode: 1998PNAS...95.5281F. 
• "Functional association of TGF-beta receptor II with cyclin B". Oncogene 18 (1): 269–75. 1999. doi:10.1038/sj.onc.1202263. PMID 9926943. 
• "Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint". Virus Res. 68 (2): 161–73. 2000. doi:10.1016/S0168-1702(00)00167-2. PMID 10958988. 
• "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2000. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
• "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. 2001. doi:10.1006/viro.2001.1007. PMID 11531413. 
• "Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression". Virology 292 (2): 321–30. 2002. doi:10.1006/viro.2001.1261. PMID 11878934.