Biology:DNA oxidative demethylase
From HandWiki
| DNA oxidative demethylase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.14.11.33 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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DNA oxidative demethylase (EC 1.14.11.33, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with systematic name methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- DNA-base-CH3 + 2-oxoglutarate + O2 [math]\displaystyle{ \rightleftharpoons }[/math] DNA-base + formaldehyde + succinate + CO2
DNA oxidative demethylase contains iron; activity is somewhat stimulated by ascorbate.
References
- ↑ "AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli". Nature 419 (6903): 178–82. September 2002. doi:10.1038/nature01048. PMID 12226668. Bibcode: 2002Natur.419..178F.
- ↑ "A non-heme iron-mediated chemical demethylation in DNA and RNA". Accounts of Chemical Research 42 (4): 519–29. April 2009. doi:10.1021/ar800178j. PMID 19852088.
- ↑ "Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase". Nature 468 (7321): 330–3. November 2010. doi:10.1038/nature09497. PMID 21068844. Bibcode: 2010Natur.468..330Y.
External links
- DNA+oxidative+demethylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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