Biology:dTDP-4-dehydro-6-deoxyglucose reductase
From HandWiki
| dTDP-4-dehydro-6-deoxyglucose reductase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.266 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase (EC 1.1.1.266) is an enzyme that catalyzes the chemical reaction
- dTDP-D-fucose + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H+
Thus, the two substrates of this enzyme are dTDP-D-fucose and NADP+, whereas its 3 products are dTDP-4-dehydro-6-deoxy-D-glucose, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-D-fucose:NADP+ oxidoreductase. This enzyme is also called dTDP-4-keto-6-deoxyglucose reductase. This enzyme participates in polyketide sugar unit biosynthesis.
References
- "A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the synthesis of thymidine diphosphate-D-fucose". J. Biol. Chem. 274 (24): 16933–9. 1999. doi:10.1074/jbc.274.24.16933. PMID 10358040.
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