Biology:Dihydrocarveol dehydrogenase

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Dihydrocarveol dehydrogenase
Identifiers
EC number1.1.1.296
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Dihydrocarveol dehydrogenase (EC 1.1.1.296, carveol dehydrogenase (ambiguous)) is an enzyme with systematic name menth-8-en-2-ol:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

menth-8-en-2-ol + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] menth-8-en-2-one + NADH + H+

This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (-)-isodihydrocarveol.

References

  1. "Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14". Microbiology 146 ( Pt 5) (5): 1129–41. May 2000. doi:10.1099/00221287-146-5-1129. PMID 10832640. 

External links