Biology:Dobrava-Belgrade orthohantavirus
| Dobrava-Belgrade orthohantavirus | |
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Virus classification 
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| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Ellioviricetes |
| Order: | Bunyavirales |
| Family: | Hantaviridae |
| Genus: | Orthohantavirus |
| Species: | Dobrava-Belgrade orthohantavirus
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| Member viruses[1] | |
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| Synonyms[2] | |
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Dobrava-Belgrade orthohantavirus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World Orthohantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated in 1985 from a yellow-necked mouse (Apodemus flavicollis) found in the village of Dobrava, southeastern Slovenia.[3][4] It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.[5]
Phylogeny
Four genotypes are described:[6]
- Dobrava, observed mostly in southeastern Europe
- Kurkino, observed throughout northern and eastern Europe
- Saaremaa, observed in Estonia and Slovakia
- Sochi, observed in the Black Sea coast region of Russia
Disease
Clinical presentation varies between the four genotypes. Dobrava is the most virulent, with a case-fatality rate (CFR) of 10 to 12%, followed by Sochi, which has a CFR greater than 6%, then Kurkino, which has a CFR 0.3% to 0.9%, and lastly Saaremaa, which seems to mainly be subclinical as illness has not been reported despite a relatively high rate of seropositivity.[6]
Natural reservoir
The four genotypes each have their own natural reservoir:[6]
- Dobrava: Yellow-necked mouse
- Kurkino: Striped field mouse
- Saaremaa: Striped field mouse
- Sochi: Black Sea field mouse
See also
- Hantavirus vaccine
- Sangassou virus
- Conjunctival suffusion
- List of cutaneous conditions
- Sweating sickness, which may have been caused by a hantavirus
- 1993 Four Corners hantavirus outbreak
References
- ↑ Briese, Thomas (July 18, 2016). "In the genus Hantavirus (proposed family Hanta viridae, proposed order Bunyavirales), created 24 new species, abolished 7 species, changed the demarcation criteria, and change the name of the genus to Orthohantavirus; likewise, rename its constituent species" (in en). https://ictv.global/ictv/proposals/2016.023a-cM.A.v2.Hantavirus_sprev.pdf.
- ↑ "ICTV Taxonomy history: Dobrava-Belgrade orthohantavirus" (in en). https://ictv.global/taxonomy/taxondetails?taxnode_id=20180033.
- ↑ "Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia". J Med Virol 38 (2): 132–7. Oct 1992. doi:10.1002/jmv.1890380211. PMID 1360999.
- ↑ Likar, Miha (1995). "Mišja mrzlica in virus Dobrava v Sloveniji" (in sl). UJMA (11): 155–160. http://www.sos112.si/slo/tdocs/ujma/1997/155_160.pdf.
- ↑ Schlegel Mathias; Klempa Boris; Auste Brita; Bemmann Margrit; Schmidt-Chanasit Jonas; Büchner Thomas; Groschup Martin H.; Meier Markus et al. (2009). "Dobrava-Belgrade Virus Spillover Infections, Germany". Emerging Infectious Diseases 15 (12): 2017–20. doi:10.3201/eid1512.090923. PMID 19961690.
- ↑ 6.0 6.1 6.2 "Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics.". Arch Virol 158 (3): 521–529. 2013. doi:10.1007/s00705-012-1514-5. PMID 23090188.
External links
- Sloan Science and Film / Short Films / Muerto Canyon by Jen Peel 29 minutes
- "Hantaviruses, with emphasis on Four Corners Hantavirus" by Brian Hjelle, M.D., Department of Pathology, School of Medicine, University of New Mexico
- CDC's Hantavirus Technical Information Index page
- Viralzone: Hantavirus
- Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae
- Occurrences and deaths in North and South America
Wikidata ☰ Q29002493 entry
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