Biology:Puumala orthohantavirus

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Short description: Human virus discovered in 1980

Puumala orthohantavirus
Virus classification e
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Genus: Orthohantavirus
Puumala orthohantavirus

Puumala orthohantavirus (PUUV) is a species of Orthohantavirus. Humans infected with the virus may develop a haemorrhagic fever with renal syndrome (HFRS) known as nephropathia epidemica. Puumala orthohantavirus HFRS is lethal in less than 0.5% of the cases.[1] Rarely, PUUV infection can cause Guillain-Barré syndrome.[2]

Puumala orthohantavirus was discovered and named in 1980 named after Puumala, a municipality in Finland .[3] The virus is found predominantly in Scandinavia and Finland , although it has also been reported elsewhere in Northern Europe, Poland and Russia . Because the bank vole (Myodes glareolus) acts as a reservoir for the virus, nephropathia epidemica cases track with the vole population in a three- to four-year cycle. Humans are infected through inhalation of dust from vole droppings.[4]It has been theorized that Puumala orthohantavirus, unlike other members of the genus Orthohantavirus, may also have lethal effects on its rodent host.[5]

In August 2014 an Israeli researcher studying the behavior of the bank vole in Finland died after contracting the Puumala orthohantavirus, which caused a complete breakdown of her immune system.[6]


  1. Discertation for doctoral exam; Distribution of Puumalavirus in Sweden , by C. Ahlm, second paragraph; latest access 2012-06-04
  2. "Guillain-Barré syndrome associated with Puumula Hantavirus infection.". Acta Clin Belg 69 (5): 371–374. 2014. doi:10.1179/0001551214Z.00000000085. PMID 25092197. 
  3. Brummer-Korvenkontio, M.; Vaheri, A.; Hovi, T.; Von Bonsdorff, C. H.; Vuorimies, J.; Manni, T.; Penttinen, K.; Oker-Blom, N. et al. (1980). "Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection". The Journal of Infectious Diseases 141 (2): 131–134. doi:10.1093/infdis/141.2.131. PMID 6102587. 
  4. "Patterns of Puumala virus infection in Finland". Euro Surveill 8 (1): 9–13. January 2003. doi:10.2807/esm.08.01.00394-en. PMID 12631978. 
  5. "Endemic hantavirus infection impairs the winter survival of its rodent host". Ecology 88 (8): 1911–6. August 2007. doi:10.1890/06-1620.1. PMID 17824420. 
  6. קלנר, ירון (8 July 2014). "קרן חקרה מכרסמים - שגרמו למותה מנגיף אלים". Ynet.,7340,L-4555889,00.html. 

Wikidata ☰ Q29002553 entry