Biology:Enzyme inducer
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An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme, either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme.[1] One of the examples of enzyme inducers can be Cytochrome P450[2] enzymes, which will help to metabolize the drugs faster in the organism. Enzyme inducers are important in the pharmaceutical field to learn drug interactions.[3] Studies show that certain drugs will increase the activity of the inducer, examples could be antibiotics.[4] It is the opposite of an enzyme repressor. There are specific types of enzyme inducers[5] that create cytoprotective pathways that play a role in prevention and treatment of cancer and other diseases including cardiovascular disease and neurodegenerative diseases.
Enzyme inducers can be either naturally occurring or synthetically made. These inducers can be naturally occurring, like compounds in cruciferous vegetables, or synthetically developed for therapeutic purposes.
See also
References
- ↑ Principles of Fermentation Technology (2nd ed.). Elsevier. 2013. ISBN 9781483292915. https://books.google.com/books?id=CW8vBQAAQBAJ. Retrieved 1 August 2016.
- ↑ Jing Li; Chengde Zhang; Shiwen Wu, Jiao Xue; Ke Chen; Zixin Deng; Dongqing Zhu (May 5, 2025). "Science Direct". https://www.sciencedirect.com%2fscience%2farticle%2fpii%2fS2667370325000207.
- ↑ Hakkola, Jukka; Hukkanen, Janne; Turpeinen, Miia; Pelkonen, Olavi (May 5, 2025). "Inhibition and induction of CYP enzymes in humans: an update". Archives of Toxicology 94 (11): 3671–3722. doi:10.1007/s00204-020-02936-7. ISSN 1432-0738. PMID 33111191.
- ↑ Chandra, D, Kale, RK. "Web of Science". https://www.webofscience.com%2fwos%2fwoscc%2ffull-record%2fWOS%3a000079259100007.
- ↑ Dinkova-Kostova, Albena T (2010). "Exceptionally Potent Inducer of Cytoprotective Enzymes: ELUCIDATION OF THE STRUCTURAL FEATURES THAT DETERMINE INDUCER POTENCY AND REACTIVITY WITH Keap1". The Journal of Biological Chemistry 285 (44): 33747–33755. doi:10.1074/jbc.M110.163485. PMID 20801881.
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