Chemistry:Endocannabinoid enhancer

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Short description: Type of cannabinoidergic drug

An endocannabinoid enhancer (eCBE) is a type of cannabinoidergic[1] drug that enhances the activity of the endocannabinoid system by increasing extracellular concentrations of endocannabinoids.[2][3][4][5] Examples of different types of eCBEs include fatty acid amide hydrolase (FAAH) inhibitors, monoacylglycerol lipase (MAGL) inhibitors, and endocannabinoid transporter (eCBT) inhibitors (or "endocannabinoid reuptake inhibitors" ("eCBRIs")).[2][3][4][5] An example of an actual eCBE is AM404, the active metabolite of the analgesic paracetamol (acetaminophen; Tylenol) and a dual FAAH inhibitor and eCBRI.[6][7][8]

See also

References

  1. ↑ George I. Papakostas; Maurizio Fava (2010). Pharmacotherapy for Depression and Treatment-resistant Depression. World Scientific. pp. 323–. ISBN 978-981-4287-59-3. https://books.google.com/books?id=zigp-66vq0MC&pg=PA323. 
  2. ↑ 2.0 2.1 Bambico, Francis Rodriguez; Gobbi, Gabriella (2008). "The cannabinoid CB1 receptor and the endocannabinoid anandamide: possible antidepressant targets". Expert Opinion on Therapeutic Targets 12 (11): 1347–1366. doi:10.1517/14728222.12.11.1347. ISSN 1472-8222. PMID 18851692. 
  3. ↑ 3.0 3.1 Di Marzo, Vincenzo (2008). "Targeting the endocannabinoid system: to enhance or reduce?". Nature Reviews Drug Discovery 7 (5): 438–455. doi:10.1038/nrd2553. ISSN 1474-1776. PMID 18446159. 
  4. ↑ 4.0 4.1 Saito, Viviane M.; Wotjak, Carsten T.; Moreira, Fabrício A. (2010). "Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?". Rev Bras Psiquiatr 32 (1): 57–514. doi:10.1590/S1516-44462010000500004. ISSN 1516-4446. PMID 20512266. 
  5. ↑ 5.0 5.1 Micale, Vincenzo; Di Marzo, Vincenzo; Sulcova, Alexandra; Wotjak, Carsten T.; Drago, Filippo (2013). "Endocannabinoid system and mood disorders: Priming a target for new therapies". Pharmacology & Therapeutics 138 (1): 18–37. doi:10.1016/j.pharmthera.2012.12.002. ISSN 0163-7258. PMID 23261685. 
  6. ↑ "Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology". J. Pharmacol. Exp. Ther. 298 (1): 7–14. 2001. PMID 11408519. 
  7. ↑ "Paracetamol (Acetaminophen): mechanisms of action". Paediatr Anaesth 18 (10): 915–21. 2008. doi:10.1111/j.1460-9592.2008.02764.x. PMID 18811827. 
  8. ↑ "Paracetamol: new vistas of an old drug". CNS Drug Rev 12 (3–4): 250–75. 2006. doi:10.1111/j.1527-3458.2006.00250.x. PMID 17227290. 




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