Biology:GPX3
From HandWiki
Short description: Enzyme in humans
 Generic protein structure example |
Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.[1][2][3]
GPx-3 belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[1]
Thiol specificity
GPx-3 has a wide thiol specificity. The sources of reducing power for GPx-3 in vitro include GSH, cysteine, mercaptoethanol, and dithiothreitol.[4] There is an evidence of effectiveness of homocysteine in reduction of GPx-3: GSH can be completely replaced by reduced homocysteine in vitro.[5][6]
Changes during ontogeny
In the rat blood plasma, the GPx-3 activity is low during the first two weeks after birth and rapidly increasing during transition from milk nutrition to solid food. Aging is accompanied by decrease in GPx-3 activity: in the blood plasma of rats it occurs around 23-26 months of age.[6]
References
- ↑ 1.0 1.1 "Entrez Gene: glutathione peroxidase 3 (plasma)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2878.
- ↑ "Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme". Archives of Biochemistry and Biophysics 256 (2): 677–86. August 1987. doi:10.1016/0003-9861(87)90624-2. PMID 3619451.
- ↑ "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenetics and Cell Genetics 66 (2): 96–8. 1994. doi:10.1159/000133675. PMID 8287691.
- ↑ "A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P". The Journal of Biological Chemistry 277 (43): 41254–8. October 2002. doi:10.1074/jbc.M202773200. PMID 12185074.
- ↑ "[Thiol peroxidase activities in rat blood plasma determined with hydrogen peroxide and 5,5'-dithio-bis(2-nitrobenzoic acid)]". Biomeditsinskaia Khimiia 62 (4): 431–8. May 2016. doi:10.18097/PBMC20166204431. PMID 27562997.
- ↑ 6.0 6.1 "Changes in the Activity of Glutathione Peroxidase in the Blood Plasma and Serum of Rats during Postnatal Development and Aging". Advances in Gerontology 9 (3): 283–288. 2019. doi:10.1134/s2079057019030147.
Further reading
- "Genetic susceptibility to distinct bladder cancer subphenotypes". European Urology 57 (2): 283–92. February 2010. doi:10.1016/j.eururo.2009.08.001. PMID 19692168.
- "Glutathione peroxidase 3 gene polymorphisms and risk of differentiated thyroid cancer". Surgery 145 (5): 508–13. May 2009. doi:10.1016/j.surg.2008.12.008. PMID 19375609.
- "The role of low levels of the serum glutathione-dependent peroxidase and glutathione and high levels of serum homocysteine in the development of cardiovascular disease". Clinical Laboratory 48 (3–4): 129–30. 2002. PMID 11934214.
- "Assessing oxidative pathway genes as risk factors for bipolar disorder". Bipolar Disorders 12 (5): 550–6. August 2010. doi:10.1111/j.1399-5618.2010.00834.x. PMID 20712757.
- "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occupational and Environmental Medicine 66 (12): 848–53. December 2009. doi:10.1136/oem.2008.044024. PMID 19773279.
- "Common genetic variants in candidate genes and risk of familial lymphoid malignancies". British Journal of Haematology 146 (4): 418–23. August 2009. doi:10.1111/j.1365-2141.2009.07790.x. PMID 19573080.
- "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respiratory Medicine 103 (12): 1866–70. December 2009. doi:10.1016/j.rmed.2009.06.016. PMID 19625176.
- "Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy". Placenta 31 (5): 401–8. May 2010. doi:10.1016/j.placenta.2010.02.011. PMID 20303587. http://eprints.nottingham.ac.uk/44258/8/Placental_GPx_final%2044258.pdf.
- "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis 29 (10): 1938–43. October 2008. doi:10.1093/carcin/bgn178. PMID 18676680.
- "Simultaneous genotyping of 11 non-synonymous SNPs in the 4 glutathione peroxidase genes using the multiplex single base extension method". Clinica Chimica Acta; International Journal of Clinical Chemistry 402 (1–2): 79–82. April 2009. doi:10.1016/j.cca.2008.12.027. PMID 19161995.
- "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics 85 (5): 628–42. November 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121.
- "Functional glutathione peroxidase 3 polymorphisms associated with increased risk of Taiwanese patients with gastric cancer". Clinica Chimica Acta; International Journal of Clinical Chemistry 411 (19–20): 1432–6. October 2010. doi:10.1016/j.cca.2010.05.026. PMID 20576521.
- "Human-specific induction of glutathione peroxidase-3 by proteasome inhibition in cardiovascular cells". Free Radical Biology & Medicine 47 (11): 1652–60. December 2009. doi:10.1016/j.freeradbiomed.2009.09.017. PMID 19766714.
- "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China". Environmental and Molecular Mutagenesis 50 (4): 285–90. May 2009. doi:10.1002/em.20452. PMID 19170196.
- "Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma". Oncology Reports 20 (6): 1299–303. December 2008. doi:10.3892/or_00000144. PMID 19020706.
- "An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer". International Journal of Oncology 36 (2): 405–14. February 2010. doi:10.3892/ijo_00000513. PMID 20043075.
- "Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells". Molecular and Cellular Biology 29 (1): 20–30. January 2009. doi:10.1128/MCB.00544-08. PMID 18936159.
- "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population". Journal of Human Genetics 55 (8): 490–4. August 2010. doi:10.1038/jhg.2010.53. PMID 20485444.
- "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy". Cancer Epidemiology, Biomarkers & Prevention 19 (3): 811–21. March 2010. doi:10.1158/1055-9965.EPI-09-0871. PMID 20200426.
- "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care 33 (10): 2250–3. October 2010. doi:10.2337/dc10-0452. PMID 20628086.
External links
- Overview of all the structural information available in the PDB for UniProt: P22352 (Glutathione peroxidase 3) at the PDBe-KB.
 |  |
