Biology:PRDX6

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene. It is a member of the peroxiredoxin family of antioxidant enzymes.

Function

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Further reading

• "Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism". Free Radical Biology & Medicine 38 (11): 1422–1432. June 2005. doi:10.1016/j.freeradbiomed.2005.02.011. PMID 15890616. 
• "Work in progress. Occurence [sic] of phospholipase A1 and A2 in human decidua". Prostaglandins 9 (5): 667–673. May 1975. doi:10.1016/0090-6980(75)90106-9. PMID 240188. 
• "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis 13 (12): 992–1001. December 1992. doi:10.1002/elps.11501301201. PMID 1286669. 
• "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". The Journal of Infection 24 (3): 317–320. May 1992. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151. 
• "Phospholipases A2 and C of human lung; subcellular distribution and substrate selectivity". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1003 (2): 189–195. June 1989. doi:10.1016/0005-2760(89)90254-3. PMID 2730891. 
• "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 2 (1): 37–43. 1995. doi:10.1093/dnares/2.1.37. PMID 7788527. 
• "Plasma and red blood cell protein maps: update 1993". Electrophoresis 14 (11): 1223–1231. November 1993. doi:10.1002/elps.11501401183. PMID 8313871. 
• "Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein". The Journal of Biological Chemistry 272 (4): 2542–2550. January 1997. doi:10.1074/jbc.272.4.2542. PMID 8999971. 
• "The human homologue of a bovine non-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene". Oncogene 14 (8): 915–921. February 1997. doi:10.1038/sj.onc.1200905. PMID 9050990. 
• "Characterization of a mammalian peroxiredoxin that contains one conserved cysteine". The Journal of Biological Chemistry 273 (11): 6303–6311. March 1998. doi:10.1074/jbc.273.11.6303. PMID 9497358. 
• "Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution". Nature Structural Biology 5 (5): 400–406. May 1998. doi:10.1038/nsb0598-400. PMID 9587003. 
• "1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities". The Journal of Biological Chemistry 275 (37): 28421–28427. September 2000. doi:10.1074/jbc.M005073200. PMID 10893423. 
• "Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress". The Journal of Biological Chemistry 276 (52): 48899–48907. December 2001. doi:10.1074/jbc.M100733200. PMID 11677226. 
• "A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress". The Biochemical Journal 366 (Pt 3): 777–785. September 2002. doi:10.1042/BJ20020525. PMID 12059788. 
• "A 29-kDa protein associated with p67phox expresses both peroxiredoxin and phospholipase A2 activity and enhances superoxide anion production by a cell-free system of NADPH oxidase activity". The Journal of Biological Chemistry 277 (47): 45181–45187. November 2002. doi:10.1074/jbc.M202869200. PMID 12121978. 
• "1-Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation-mediated membrane damage". Proceedings of the National Academy of Sciences of the United States of America 99 (18): 11599–11604. September 2002. doi:10.1073/pnas.182384499. PMID 12193653. Bibcode: 2002PNAS...9911599M. 
• "Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders". Brain Research 967 (1–2): 152–160. March 2003. doi:10.1016/S0006-8993(02)04243-9. PMID 12650976. 
• "Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid". Diabetes 67 (6): 1190–1199. June 2018. doi:10.2337/db17-1087. PMID 29549163.