Biology:GPX5
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.[1][2]
GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: glutathione peroxidase 5 (epididymal androgen-related protein)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2880.
- ↑ "The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract". Biochem. J. 333 (1): 5–9. July 1998. doi:10.1042/bj3330005. PMID 9639555.
Further reading
- "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121.
- "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M.
- "Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon.". Biochem. J. 285 (3): 863–70. 1992. doi:10.1042/bj2850863. PMID 1386734.
- "Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation.". Arch. Biochem. Biophys. 386 (2): 213–20. 2001. doi:10.1006/abbi.2000.2197. PMID 11368344.
- "Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor.". Arch. Biochem. Biophys. 351 (1): 17–26. 1998. doi:10.1006/abbi.1997.0566. PMID 9501919.
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2000. doi:10.1101/gr.143000. PMID 11076863.
- "GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations.". Mol. Reprod. Dev. 63 (1): 96–103. 2002. doi:10.1002/mrd.10136. PMID 12211066.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice.". J. Biol. Chem. 275 (5): 3693–8. 2000. doi:10.1074/jbc.275.5.3693. PMID 10652368.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase.". Mol. Reprod. Dev. 47 (1): 87–98. 1997. doi:10.1002/(SICI)1098-2795(199705)47:1<87::AID-MRD12>3.0.CO;2-X. PMID 9110319.
- "HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells.". Brain Res. 1045 (1–2): 57–63. 2005. doi:10.1016/j.brainres.2005.03.031. PMID 15910762.
- "Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract.". Mol. Hum. Reprod. 4 (9): 841–8. 1998. doi:10.1093/molehr/4.9.841. PMID 9783843.
- "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. 2010. doi:10.2337/dc10-0452. PMID 20628086.
- "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.". Cancer Epidemiol. Biomarkers Prev. 19 (3): 811–21. 2010. doi:10.1158/1055-9965.EPI-09-0871. PMID 20200426.
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