Biology:Galactose 1-dehydrogenase (NADP+)
From HandWiki
Short description: Enzyme class
| galactose 1-dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.120 | ||||||||
| CAS number | 37250-51-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a galactose 1-dehydrogenase (NADP+) (EC 1.1.1.120) is an enzyme that catalyzes the chemical reaction
- D-galactose + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] D-galactonolactone + NADPH + H+
Thus, the two substrates of this enzyme are D-galactose and NADP+, whereas its 3 products are D-galactonolactone, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-galactose:NADP+ 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase (NADP+), and galactose 1-dehydrogenase (NADP+). This enzyme participates in galactose metabolism.
References
- "The isolation of three sugar dehydrogenases from a psuedomonad [sic]". J. Biol. Chem. 240 (11): 4488–92. 1965. PMID 5845847.
- "Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4493–7. 1965. PMID 5845848.
- "Some physical properties of three sugar dehydrogenases from a pseudomonad". J. Biol. Chem. 240 (11): 4498–502. 1965. PMID 5845849.
- "Über den Abbau der Desoxyzucker durch Bakterienenzyme, V. Anreicherung und Charakterisierung einer NADP-abhängigen Abequosedehydrogenase aus Pseudomonas putida" (in German). Hoppe-Seyler's Z. Physiol. Chem. 349 (10): 1321–9. 1968. doi:10.1515/bchm2.1968.349.2.1321. PMID 4387016.
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