Biology:Galactoside acetyltransferase
From HandWiki
| Galactoside O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.18 | ||||||||
| CAS number | 9029-94-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Thiogalactoside acetyltransferase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | lacA | ||||||
| Entrez | 945674 | ||||||
| RefSeq (Prot) | NP_414876 | ||||||
| UniProt | P07464 | ||||||
| |||||||
Galactoside acetyltransferase (also known as Galactoside O-acetyltransferase, thiogalactoside transacetylase, β-galactoside transacetylase and GAT) is an enzyme that transfers an acetyl group from acetyl-CoA to β-galactosides, glucosides and lactosides. It is coded for by the lacA gene of the lac operon in E. coli.[1]
Reaction
It catalyzes the following reaction:
acetyl-CoA + beta-D-galactoside → CoA + 6-acetyl-beta-D-galactoside
The kinetics of the enzyme were delineated in 1995.[2]
Biological role
The enzyme's role in the classical E.coli lac operon remains unclear.[1][3] However, the enzyme's cellular role may be to detoxify non-metabolizable pyranosides by acetylating them and preventing their reentry into the cell.[1][4]
See also
- Transacetylase
References
- ↑ 1.0 1.1 1.2 "Structure of the lac operon galactoside acetyltransferase". Structure 10 (4): 581–8. April 2002. doi:10.1016/S0969-2126(02)00741-4. PMID 11937062.
- ↑ "Structural and mechanistic studies of galactoside acetyltransferase, the Escherichia coli LacA gene product". The Journal of Biological Chemistry 270 (44): 26326–31. November 1995. doi:10.1074/jbc.270.44.26326. PMID 7592843.
- ↑ "The lac operon galactoside acetyltransferase". Comptes Rendus Biologies 328 (6): 568–75. June 2005. doi:10.1016/j.crvi.2005.03.005. PMID 15950163. https://comptes-rendus.academie-sciences.fr/biologies/articles/10.1016/j.crvi.2005.03.005/.
- ↑ Thiogalactoside transacetylase of the lactose operon as an enzyme for detoxification.. 1976. http://jb.asm.org/content/128/1/510.abstract.
External links
- galactoside+acetyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.3.1.18
 |  |
