Biology:Glycerol-3-phosphate dehydrogenase (quinone)

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Glycerol-3-phosphate dehydrogenase
2r46.jpg
Glycerol-3-phosphate dehydrogenase monomer + FAD, E.Coli
Identifiers
EC number1.1.5.3
CAS number9001-49-4
Alt. namesvalpha-glycerophosphate dehydrogenase, alpha-glycerophosphate dehydrogenase (acceptor), anaerobic glycerol-3-phosphate dehydrogenase, DL-glycerol 3-phosphate oxidase (misleading), FAD-dependent glycerol-3-phosphate dehydrogenase, FAD-dependent sn-glycerol-3-phosphate dehydrogenase, FAD-GPDH, FAD-linked glycerol 3-phosphate dehydrogenase, FAD-linked L-glycerol-3-phosphate dehydrogenase, flavin-linked glycerol-3-phosphate dehydrogenase, flavoprotein-linked L-glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate cytochrome c reductase (misleading), glycerol phosphate dehydrogenase, glycerol phosphate dehydrogenase (acceptor), glycerol phosphate dehydrogenase (FAD), glycerol-3-phosphate CoQ reductase, glycerol-3-phosphate dehydrogenase (flavin-linked), glycerol-3-phosphate:CoQ reductase, glycerophosphate dehydrogenase, L-3-glycerophosphate-ubiquinone oxidoreductase, L-glycerol-3-phosphate dehydrogenase (ambiguous), L-glycerophosphate dehydrogenase, mGPD, mitochondrial glycerol phosphate dehydrogenase, NAD+-independent glycerol phosphate dehydrogenase, pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase, sn-glycerol 3-phosphate oxidase (misleading), sn-glycerol-3-phosphate dehydrogenase, sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase, sn-glycerol-3-phosphate:acceptor 2-oxidoreductase)
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3 is an enzyme with systematic name sn-glycerol 3-phosphate:quinone oxidoreductase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction

sn-glycerol 3-phosphate + quinone [math]\displaystyle{ \rightleftharpoons }[/math] glycerone phosphate + quinol

This flavin-dependent dehydrogenase is a membrane enzyme. It participates in glycolysis, respiration and phospholipid biosynthesis.

References

  1. "Studies on the mitochondrial alpha-glycerophosphate dehydrogenase. II. Extraction and partial purification of the dehydrogenase from pig brain". The Journal of Biological Chemistry 236: 1192–8. April 1961. PMID 13741763. 
  2. "Chemical and functional properties of the native and reconstituted forms of the membrane-bound, aerobic glycerol-3-phosphate dehydrogenase of Escherichia coli". The Journal of Biological Chemistry 253 (3): 783–8. February 1978. PMID 340460. 
  3. "Calcium activation of mitochondrial glycerol phosphate dehydrogenase restudied". Archives of Biochemistry and Biophysics 326 (1): 79–84. February 1996. doi:10.1006/abbi.1996.0049. PMID 8579375. 
  4. "Steady-state kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria". Archives of Biochemistry and Biophysics 344 (1): 235–41. August 1997. doi:10.1006/abbi.1997.0150. PMID 9244403. 
  5. "Identification of a mitochondrial glycerol-3-phosphate dehydrogenase from Arabidopsis thaliana: evidence for a mitochondrial glycerol-3-phosphate shuttle in plants". FEBS Letters 536 (1-3): 92–6. February 2003. doi:10.1016/s0014-5793(03)00033-4. PMID 12586344. 
  6. "Aerobic sn-glycerol-3-phosphate dehydrogenase from Escherichia coli binds to the cytoplasmic membrane through an amphipathic alpha-helix". The Biochemical Journal 365 (Pt 2): 471–9. July 2002. doi:10.1042/BJ20011853. PMID 11955283. 
  7. "The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation". The EMBO Journal 16 (9): 2179–87. May 1997. doi:10.1093/emboj/16.9.2179. PMID 9171333. 
  8. "The importance of the glycerol 3-phosphate shuttle during aerobic growth of Saccharomyces cerevisiae". Yeast 14 (4): 347–57. March 1998. doi:10.1002/(SICI)1097-0061(19980315)14:4<347::AID-YEA226>3.0.CO;2-9. PMID 9559543. 

External links