Biology:Glycine N-acyltransferase
| glycine N-acyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.13 | ||||||||
| CAS number | 9029-95-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a glycine N-acyltransferase (GLYAT), also known as acyl-CoA:glycine N-acyltransferase (ACGNAT), (EC 2.3.1.13) is an enzyme that catalyzes the chemical reaction
- acyl-CoA + glycine [math]\displaystyle{ \rightleftharpoons }[/math] CoA + N-acylglycine
Thus, the two substrates of this enzyme are acyl-CoA and glycine, whereas its two products are CoA and N-acylglycine. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:glycine N-acyltransferase. Other names in common use include glycine acyltransferase, and glycine-N-acylase.
This enzyme plays a prominent role in converting benzoic acid (benzoate) into hippuric acid (N-benzoylglycine). Benzoic acid is metabolized by butyrate-CoA ligase into an intermediate product, benzoyl-CoA,[1] which is then metabolized by glycine N-acyltransferase into hippuric acid.[2]
References
- "Benzoyl-coenzyme A:glycine N-acyltransferase and phenylacetyl-coenzyme A:glycine N-acyltransferase from bovine liver mitochondria. Purification and characterization". J. Biol. Chem. 254 (15): 7230–7. 1979. PMID 457678.
- "Glycine N-acylase: purification and properties". J. Biol. Chem. 208 (1): 263–75. 1954. PMID 13174534.
- "Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man". J. Biol. Chem. 251 (11): 3352–8. 1976. PMID 931988.
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