Biology:Hantaan River virus

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Hantaan virus
Virus classification
Group V ((−)ssRNA)
Hantaan virus

Hantaan virus (HTNV) is an enveloped, single-stranded, negative-sense RNA virus species of Old World Orthohantavirus. It is the causative agent of Korean Hemorrhagic Fever in humans.[1][2]

Natural reservoir

Apodemus agrarius, also known as striped field mouse, is the etiological agent of Hantaan virus.[3]


Transmission is believed to be through inhalation of aersolized rodent urine and feces.

Morbidity and mortality

In hantavirus induced hemorrhagic fever, incubation time is between two and four weeks in humans before symptoms of infection present. Severity of symptoms depends on the viral load. Like Dobrava-Belgrade virus, Hantaan virus has a mortality rate of 10 to 12%.[4][5]


During the Korean War (1951–1953), more than 3000 American and Korean troops fell ill with renal failure, hemorrhage, and shock. The cause remained unknown until 1976 when Karl M. Johnson an American tropical virologist and his colleagues, including Korean virologist, Lee Ho Wang (Ho Wang Lee), isolated Hantaan virus from the lungs of striped field mice.[1][2]

See also


  1. 1.0 1.1 "Hantavirus infection—haemorrhagic fever in the Balkans—potential nephrological hazards in the Kosovo war". 2013-04-04. Retrieved 2013-04-13. 
  2. 2.0 2.1 "Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever, from wild urban rats". J Infect Dis 146: 638–644. 1982. doi:10.1093/infdis/146.5.638. PMID 6127366. 
  3. "The Murine Model for Hantaan virus-Induced Lethal Disease Shows Two Distinct Paths in Viral Evolutionary Trajectory with or without Ribavirin Treatment". 2013-07-31. Retrieved 2013-09-29. 
  4. Yi J.; Xu Z.; Zhuang R.; Wang J.; Zhang Y.; Ma Y.; Liu B.; Zhang Y. et al. (2013). "Hantaan Virus RNA Load in Patients Having Hemorrhagic Fever With Renal Syndrome: Correlation With Disease Severity". Journal of Infectious Diseases (Oxford Journals) 207 (9): 1457–1461. doi:10.1093/infdis/jis475. PMID 22869912. 
  5. Klenk, Feldmann Heinz; Pavlovic Jovan; Anheier Bärbel; Haller Otto; Hans-Dieter; Wichmann Dominic; Gröne Hermann-Josef; Frese Michael (2002). "Neurological Disease That Is Fatal in Adult with Hantaan Virus Infection". J. Virol. 76 (17): 8890–8899. 

External links

Wikidata ☰ Q29002506 entry