Biology:IMPDH2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.

Function

IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A

Clinical significance

This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.

See also

• IMP dehydrogenase

Further reading

• "IMPDH2 genetic polymorphism: a promoter single-nucleotide polymorphism disrupts a cyclic adenosine monophosphate responsive element". Genet Test Mol Biomarkers 13 (6): 841–7. 2009. doi:10.1089/gtmb.2009.0096. PMID 19810816. 
• "A novel variant L263F in human inosine 5'-monophosphate dehydrogenase 2 is associated with diminished enzyme activity". Pharmacogenet. Genomics 17 (4): 283–90. 2007. doi:10.1097/FPC.0b013e328012b8cf. PMID 17496727. 
• "Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (1): 103–13. 2010. doi:10.1002/ajmg.b.30961. PMID 19367581. http://ir.psych.ac.cn/handle/311026/10097. 
• "Association of four DNA polymorphisms with acute rejection after kidney transplantation". Transpl. Int. 21 (9): 879–91. 2008. doi:10.1111/j.1432-2277.2008.00679.x. PMID 18444945. 
• "Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients". The Journal of Heart and Lung Transplantation 29 (5): 509–516. 2010. doi:10.1016/j.healun.2009.11.602. PMID 20061166. 
• "Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism". Pharmacogenet. Genomics 19 (8): 626–34. 2009. doi:10.1097/FPC.0b013e32832f5f1b. PMID 19617864. 
• "Prognostic significance of drug-regulated genes in high-grade osteosarcoma". Mod. Pathol. 20 (10): 1085–94. 2007. doi:10.1038/modpathol.3800937. PMID 17660802. 
• "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569. 
• "Identification of IMPDH2 as a tumor-associated antigen in colorectal cancer using immunoproteomics analysis". Int J Colorectal Dis 24 (11): 1271–9. 2009. doi:10.1007/s00384-009-0759-2. PMID 19597826. 
• "Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells". FEBS J. 272 (3): 696–710. 2005. doi:10.1111/j.1742-4658.2004.04504.x. PMID 15670151. 
• "An inosine 5'-monophosphate dehydrogenase 2 single-nucleotide polymorphism impairs the effect of mycophenolic acid". Pharmacogenomics J. 10 (1): 70–6. 2010. doi:10.1038/tpj.2009.43. PMID 19770842. 
• "Effect of diabetes mellitus on mycophenolate sodium pharmacokinetics and inosine monophosphate dehydrogenase activity in stable kidney transplant recipients". Ther Drug Monit 29 (6): 735–42. 2007. doi:10.1097/FTD.0b013e31815d8ace. PMID 18043470. 
• "Expression of inosine monophosphate dehydrogenase type I and type II after mycophenolate mofetil treatment: a 2-year follow-up in kidney transplantation". Clin. Pharmacol. Ther. 83 (2): 328–35. 2008. doi:10.1038/sj.clpt.6100300. PMID 17713475. 
• "Interpopulation variation frequency of human inosine 5'-monophosphate dehydrogenase type II (IMPDH2) genetic polymorphisms". Genet. Test. 12 (4): 513–6. 2008. doi:10.1089/gte.2008.0049. PMID 18976158. 
• "Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells". Cell Cycle 7 (15): 2392–400. 2008. doi:10.4161/cc.6390. PMID 18677108. 
• "Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase". Bioorg. Med. Chem. 16 (15): 7462–9. 2008. doi:10.1016/j.bmc.2008.06.003. PMID 18583139. 
• "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochem. Biophys. Res. Commun. 337 (4): 1308–18. 2005. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267. 
• "Genetic variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS genes in Japanese individuals". Drug Metab. Pharmacokinet. 24 (6): 557–64. 2009. doi:10.2133/dmpk.24.557. PMID 20045992. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.