Biology:IRAK3
 Generic protein structure example |
Interleukin-1 receptor-associated kinase 3 (originally IRAK-M) is an enzyme that in humans is encoded by the IRAK3 gene.[1][2] The IRAK family of proteins consists of two active serine/threonine kinases IRAK-1 and IRAK-4, as well as two inactive kinases IRAK-2 and IRAK-3. The activity of IRAK-3 is induced by toll-like receptor and interleukin-1 receptor signaling. IRAK-3 acts as a negative regulator for downstream signaling through these pathways by preventing the phosphorylation of IRAK-1 and IRAK-4 or by inhibiting their dissociation from the Mydd88 complex. [3] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.[4]
References
- ↑ "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry 274 (27): 19403–10. July 1999. doi:10.1074/jbc.274.27.19403. PMID 10383454.
- ↑ "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11213.
- ↑ "IRAK-M is a negative regulator of Toll-like receptor signaling". Cell 110 (2): 191-202. July 2002. doi:10.1016/s0092-8674(02)00827-9. PMID 12150927.
- ↑ "Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury". Cell Death Discovery 4 (60). May 2018. doi:10.1038/s41420-018-0056-3. PMID 29796309.
Further reading
- "Identification and characterization of murine IRAK-M". Biochemical and Biophysical Research Communications 293 (5): 1472–7. May 2002. doi:10.1016/S0006-291X(02)00411-4. PMID 12054681. Bibcode: 2002BBRC..293.1472R.
- "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry 278 (27): 24526–32. July 2003. doi:10.1074/jbc.M303451200. PMID 12721283.
- "Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients". Biochemical and Biophysical Research Communications 311 (2): 465–72. November 2003. doi:10.1016/j.bbrc.2003.10.019. PMID 14592437. Bibcode: 2003BBRC..311..465E.
- "Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4". Journal of Immunology 174 (5): 3032–40. March 2005. doi:10.4049/jimmunol.174.5.3032. PMID 15728517.
- "Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling". Cellular Signalling 19 (7): 1596–601. July 2007. doi:10.1016/j.cellsig.2007.02.009. PMID 17379480.
- "IRAK-M is involved in the pathogenesis of early-onset persistent asthma". American Journal of Human Genetics 80 (6): 1103–14. June 2007. doi:10.1086/518259. PMID 17503328.
- "Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases". Scandinavian Journal of Gastroenterology 42 (7): 827–33. July 2007. doi:10.1080/00365520601114024. PMID 17558906.
- "Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model". Journal of Immunology 179 (10): 7110–20. November 2007. doi:10.4049/jimmunol.179.10.7110. PMID 17982103.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9Y616 (Interleukin-1 receptor-associated kinase 3) at the PDBe-KB.
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