Biology:IRGM
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is encoded by the IRGM gene.[1]
IRGM is a member of the interferon-inducible GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens.
The gene has been disabled by an Alu element for at least 25 million years in the primate lineage leading to great apes including humans, but it was re-enabled by an endogenous retrovirus called ERV-9.[2]
Clinical relevance
Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[3]
References
- ↑ "Entrez Gene: immunity-related GTPase family". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=345611.
- ↑ "Death and resurrection of the human IRGM gene". PLOS Genetics 5 (3): e1000403. March 2009. doi:10.1371/journal.pgen.1000403. PMID 19266026.
- ↑ "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Human Molecular Genetics 19 (9): 1828–39. May 2010. doi:10.1093/hmg/ddq041. PMID 20106866. PMC 2850616. https://dash.harvard.edu/bitstream/handle/1/4706587/2850616.pdf?sequence=1.
Further reading
- "Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis". PLOS ONE 5 (11): e13795. November 2010. doi:10.1371/journal.pone.0013795. PMID 21072187. Bibcode: 2010PLoSO...513795L.
- "Genetic risk profiling and prediction of disease course in Crohn's disease patients". Clinical Gastroenterology and Hepatology 7 (9): 972–980.e2. September 2009. doi:10.1016/j.cgh.2009.05.001. PMID 19422935.
- "Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach". Genes and Immunity 10 (4): 356–64. June 2009. doi:10.1038/gene.2009.25. PMID 19491842.
- "Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains". PLOS Pathogens 5 (9): e1000577. September 2009. doi:10.1371/journal.ppat.1000577. PMID 19750224.
- "Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis". Clinica Chimica Acta; International Journal of Clinical Chemistry 411 (21–22): 1645–9. November 2010. doi:10.1016/j.cca.2010.06.009. PMID 20547146.
- "Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease". Human Immunology 70 (11): 946–9. November 2009. doi:10.1016/j.humimm.2009.08.004. PMID 19683022.
- "Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates". Genome Biology 11 (3): R26. 2010. doi:10.1186/gb-2010-11-3-r26. PMID 20210993.
- "Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?". European Journal of Gastroenterology & Hepatology 22 (8): 933–7. August 2010. doi:10.1097/MEG.0b013e32833775e6. PMID 20395867.
- "Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria". Nature Cell Biology 12 (12): 1154–65. December 2010. doi:10.1038/ncb2119. PMID 21102437.
- "Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease". Inflammatory Bowel Diseases 16 (7): 1108–17. July 2010. doi:10.1002/ibd.21176. PMID 20024904.
- "Autophagy and pattern recognition receptors in innate immunity". Immunological Reviews 227 (1): 189–202. January 2009. doi:10.1111/j.1600-065X.2008.00725.x. PMID 19120485.
- "Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients". Inflammatory Bowel Diseases 16 (6): 907–9. June 2010. doi:10.1002/ibd.21105. PMID 19760754.
- "A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles". Genes and Immunity 12 (1): 51–8. January 2011. doi:10.1038/gene.2010.47. PMID 20962850.
- "Human IRGM gene "to be or not to be"". Seminars in Immunopathology 32 (4): 437–44. December 2010. doi:10.1007/s00281-010-0224-x. PMID 20737271.
- "Molecular reclassification of Crohn's disease by cluster analysis of genetic variants". PLOS ONE 5 (9): e12952. September 2010. doi:10.1371/journal.pone.0012952. PMID 20886065. Bibcode: 2010PLoSO...512952C.
- "Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort". PLOS ONE 5 (11): e15376. November 2010. doi:10.1371/journal.pone.0015376. PMID 21079743. Bibcode: 2010PLoSO...515376W.
- "NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients". World Journal of Gastroenterology 16 (41): 5233–40. November 2010. doi:10.3748/wjg.v16.i41.5233. PMID 21049557.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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