Biology:Indole-3-acetaldehyde reductase (NADPH)
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Short description: Class of enzymes
| indole-3-acetaldehyde reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.191 | ||||||||
| CAS number | 58875-05-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an indole-3-acetaldehyde reductase (NADPH) (EC 1.1.1.191) is an enzyme that catalyzes the chemical reaction
- (indol-3-yl)ethanol + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] (indol-3-yl)acetaldehyde + NADPH + H+
Thus, the two substrates of this enzyme are (indol-3-yl)ethanol and NADP+, whereas its 3 products are (indol-3-yl)acetaldehyde, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (indol-3-yl)ethanol:NADP+ oxidoreductase. Other names in common use include indoleacetaldehyde (reduced nicotinamide adenine dinucleotide, phosphate) reductase, indole-3-acetaldehyde reductase (NADPH), and indole-3-ethanol:NADP+ oxidoreductase. This enzyme participates in tryptophan metabolism.
References
- "Isolation and characterization of indole-3-acetaldehyde reductases from Cucumis sativus". J. Biol. Chem. 251 (4): 907–13. 1976. PMID 2607.
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