Biology:Isocitrate—homoisocitrate dehydrogenase
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Short description: Class of enzymes
| isocitrate—homoisocitrate dehydrogenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.1.1.286 | ||||||||
| CAS number | 9001-58-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Isocitrate—homoisocitrate dehydrogenase is an enzyme that catalyzes the following two reactions:
- isocitrate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-oxoglutarate + CO2 + NADH
- homoisocitrate + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 2-oxoadipate + CO2 + NADH + H+
References
- "Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase". Biochemical and Biophysical Research Communications 331 (1): 341–6. May 2005. doi:10.1016/j.bbrc.2005.03.169. PMID 15845397.
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