Biology:KLK1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.[1][2][3] KLK1 is a member of the peptidase S1 family.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.[4]
See also
References
- ↑ "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics 11 (1): 77–82. September 1991. doi:10.1016/0888-7543(91)90103-L. PMID 1684954.
- ↑ "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry 387 (6): 637–641. June 2006. doi:10.1515/BC.2006.082. PMID 16800724.
- ↑ "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723.
- ↑ "Entrez Gene: KLK1 kallikrein 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3816.
Further reading
- "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions". Biological Chemistry 382 (1): 5–14. January 2001. doi:10.1515/BC.2001.002. PMID 11258672.
- "N-Terminal amino acid sequence of human urinary kallikrein homology with other serine proteases". Hoppe-Seyler's Zeitschrift für Physiologische Chemie 360 (12): 1947–1950. December 1979. PMID 393608.
- "Characterization of the human kallikrein locus". Genomics 14 (1): 6–11. September 1992. doi:10.1016/S0888-7543(05)80275-7. PMID 1385301.
- "Expression of the gene coding for human prostate-specific antigen and related hGK-1 in benign and malignant tumors of the human prostate". International Journal of Cancer 45 (4): 654–660. April 1990. doi:10.1002/ijc.2910450414. PMID 1691151.
- "Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in situ hybridization". Human Heredity 41 (4): 222–226. 1992. doi:10.1159/000154005. PMID 1783409.
- "Human urinary kallikrein. Complete amino acid sequence and sites of glycosylation". International Journal of Peptide and Protein Research 33 (4): 237–249. April 1989. doi:10.1111/j.1399-3011.1989.tb01277.x. PMID 2666327.
- "Cloning and expression of human salivary-gland kallikrein in Escherichia coli". The Biochemical Journal 262 (3): 787–793. September 1989. doi:10.1042/bj2620787. PMID 2686621.
- "Structure and chromosomal localization of the human renal kallikrein gene". Biochemistry 27 (9): 3124–3129. May 1988. doi:10.1021/bi00409a003. PMID 2898948.
- "Nucleotide sequence of cloned cDNA for human pancreatic kallikrein". Biochemistry 24 (27): 8037–8043. December 1985. doi:10.1021/bi00348a030. PMID 3004571.
- "Human urinary kallikrein--amino acid sequence and carbohydrate attachment sites". Protein Sequences & Data Analysis 1 (3): 177–182. February 1988. PMID 3163150.
- "N-terminal amino acid sequence of human urinary prokallikrein". Journal of Biochemistry 99 (3): 989–992. March 1986. doi:10.1093/oxfordjournals.jbchem.a135563. PMID 3635530.
- "Human kidney kallikrein: cDNA cloning and sequence analysis". DNA 4 (6): 445–450. December 1985. doi:10.1089/dna.1985.4.445. PMID 3853975.
- "Evaluation of the extent of the binding site in human tissue kallikrein by synthetic substrates with sequences of human kininogen fragments". The Biochemical Journal 312 ( Pt 1) (Pt 1): 233–238. November 1995. doi:10.1042/bj3120233. PMID 7492318.
- "Molecular cloning, purification and in situ localization of human colon kallikrein". The Biochemical Journal 307 ( Pt 2) (Pt 2): 481–486. April 1995. doi:10.1042/bj3070481. PMID 7733886.
- "Glandular kallikrein gene expression in the human uterus". Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas 27 (8): 1855–1863. August 1994. PMID 7749374.
- "Molecular cloning and sequence analysis of the monkey and human tissue kallikrein genes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1173 (3): 325–328. June 1993. doi:10.1016/0167-4781(93)90131-v. PMID 7916636.
- "Characterization of kininogenase activity of an acidic proteinase isolated from human kidney". Canadian Journal of Physiology and Pharmacology 75 (6): 757–761. June 1997. doi:10.1139/cjpp-75-6-757. PMID 9276160. http://repositorio.unifesp.br/handle/11600/25730.
- "Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2". The Journal of Biological Chemistry 272 (47): 29590–29595. November 1997. doi:10.1074/jbc.272.47.29590. PMID 9368023.
- "Reactive-site specificity of human kallistatin toward tissue kallikrein probed by site-directed mutagenesis". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1479 (1–2): 237–246. June 2000. doi:10.1016/S0167-4838(00)00044-3. PMID 10862973.
External links
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