Biology:Leukotriene-A4 hydrolase
From HandWiki
| leukotriene-A4 hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.3.2.6 | ||||||||
| CAS number | 90119-07-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| leukotriene A4 hydrolase | |
|---|---|
 Crystallographic structure of LTA4H (rainbow colored N-terminus = blue, C-terminus = red) complexed with the protease inhibitor bestatin (space-filling model, carbon = white, oxygen = red, nitrogen = blue) based on the PDB: 1HS6 structure. | |
| Identifiers | |
| Symbol | LTA4H |
| NCBI gene | 4048 |
| HGNC | 6710 |
| OMIM | 151570 |
| PDB | 1SQM |
| RefSeq | NM_000895 |
| UniProt | P09960 |
| Other data | |
| EC number | 3.3.2.6 |
| Locus | Chr. 12 q22 |
Leukotriene A4 hydrolase, also known as LTA4H is a human gene.[1][2][3] The protein encoded by this gene is a bifunctional enzyme (EC 3.3.2.6) which converts leukotriene A4 to leukotriene B4 and acts as an aminopeptidase.[4]
Function
This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds (ether hydrolases). The systematic name of this enzyme class is (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase. Other names in common use include LTA4 hydrolase, LTA4H, and leukotriene A4 hydrolase. This enzyme participates in arachidonic acid metabolism.
Catalyzed reaction
Structure
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1GW6, 1H19, 1HS6, and 1SQM.
References
- ↑ "Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. Complete primary structure of an enzyme involved in eicosanoid synthesis". J. Biol. Chem. 262 (29): 13873–6. October 1987. doi:10.1016/S0021-9258(18)47872-6. PMID 3654641. http://www.jbc.org/cgi/content/abstract/262/29/13873.
- ↑ "Molecular cloning and amino acid sequence of leukotriene A4 hydrolase". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6677–81. October 1987. doi:10.1073/pnas.84.19.6677. PMID 2821541. Bibcode: 1987PNAS...84.6677F.
- ↑ "Cloning and characterization of the human leukotriene A4 hydrolase gene". Eur. J. Biochem. 231 (1): 65–71. July 1995. doi:10.1111/j.1432-1033.1995.tb20671.x. PMID 7628486.
- ↑ "Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates". J. Biol. Chem. 279 (26): 27376–82. June 2004. doi:10.1074/jbc.M401031200. PMID 15078870.
Further reading
- "Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils". Biochim. Biophys. Acta 840 (1): 43–50. 1985. doi:10.1016/0304-4165(85)90160-6. PMID 3995081.
- "Molecular cloning of a cDNA coding for human leukotriene A4 hydrolase. Complete primary structure of an enzyme involved in eicosanoid synthesis". J. Biol. Chem. 262 (29): 13873–6. 1987. doi:10.1016/S0021-9258(18)47872-6. PMID 3654641.
- "Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase". J. Biol. Chem. 261 (14): 6332–7. 1986. doi:10.1016/S0021-9258(19)84567-2. PMID 3009453.
- "Epoxide hydrolases: their roles and interactions with lipid metabolism". Prog. Lipid Res. 44 (1): 1–51. 2005. doi:10.1016/j.plipres.2004.10.001. PMID 15748653.
- "Epoxide hydrolases: biochemistry and molecular biology". Chem. Biol. Interact. 129 (1–2): 41–59. 2000. doi:10.1016/S0009-2797(00)00197-6. PMID 11154734. http://www.personal.psu.edu/faculty/c/j/cjo10/PDFs/FretlandEHRev-2000.pdf.
- "The bifunctional enzyme leukotriene-A4 hydrolase is an arginine aminopeptidase of high efficiency and specificity". J. Biol. Chem. 269 (15): 11269–73. 1994. doi:10.1016/S0021-9258(19)78120-4. PMID 8157657.
- "Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers". J. Biol. Chem. 262 (21): 10200–5. 1987. doi:10.1016/S0021-9258(18)61098-1. PMID 3038871.
External links
- leukotriene A4 hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
