Chemistry:AM-679 (FLAP inhibitor)
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Short description: Chemical compound
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| Formula | C40H44N4O5S |
| Molar mass | 692.88 g·mol−1 |
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AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM-679 has anti-inflammatory effects in animal studies.[1][2]
References
- ↑ "5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor". Bioorganic & Medicinal Chemistry Letters 20 (1): 213–217. January 2010. doi:10.1016/j.bmcl.2009.10.131. PMID 19914828.
- ↑ "A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye". Clinical and Vaccine Immunology 16 (11): 1654–1659. November 2009. doi:10.1128/CVI.00220-09. PMID 19759251.
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