Biology:MMP16

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.[1][2]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.[2]

References

  1. "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family". J Biol Chem 270 (39): 23013–20. Nov 1995. doi:10.1074/jbc.270.39.23013. PMID 7559440. 
  2. 2.0 2.1 "Entrez Gene: MMP16 matrix metallopeptidase 16 (membrane-inserted)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4325. 

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: M10.016
  • Overview of all the structural information available in the PDB for UniProt: P51512 (Matrix metalloproteinase-16) at the PDBe-KB.